Research Article Interleukin-27-924A/G gene polymorphism is associated with Rheumatoid Arthritis in Egyptian population
نویسندگان
چکیده
منابع مشابه
CD226 rs763361 (Gly307Ser) Polymorphism Is Associated with Susceptibility to Rheumatoid Arthritis in Zahedan, Southeast Iran
Background: Rheumatoid arthritis (RA) is a chronic inflammatory disease with many genetic factors predisposing to disease susceptibility. The aim of the present study was to investigate the impact of CD226 rs727088 and rs763361 polymorphisms and susceptibility to RA in a sample of the Iranian population. Methods: This case-control study was carried out on 100 patients with RA and 104 healthy su...
متن کاملInterleukin-21 gene polymorphism rs2221903 is associated with disease activity in patients with rheumatoid arthritis
INTRODUCTION Interleukin-21 (IL-21) is a cytokine which plays a significant role in the pathogenesis and disease activity of rheumatoid arthritis (RA). Genetic polymorphisms in the IL-21 gene may alter the synthesis of IL-21. The aim of this study was to examine IL-21 and IL-21R polymorphisms in patients with RA. MATERIAL AND METHODS We examined 422 patients with RA and 338 healthy controls. ...
متن کاملLevels of Interleukin 33 and Interleukin 27 in Rheumatoid Arthritis and Osteoarthritis Egyptian patients
Background: Cytokines are important mediators of immune functions in humans and animals. IL-27, an IL-12 family cytokine, exerts a critical role in immune regulation in the context of infection and autoimmunity. IL-33, a newly foundIL-1 family cytokine is involved in joint inflammation in rheumatoid arthritis (RA). So, we aimed to investigate the immunopathological roles of IL-27 and IL-33 in s...
متن کاملInterleukin-18 promoter polymorphisms in Egyptian patients with rheumatoid arthritis.
The aim of this study was to investigate the association of interleukin-18 (IL-18) promoter single nucleotide polymorphisms (SNPs) at - 607 and - 137 regions with risk for rheumatoid arthritis (RA) and their association with activity and severity of the disease. The study included 80 RA patients and 80 age and sex matched healthy subjects. Forty RA patients and 40 control subjects were randomly...
متن کاملRelationship between IL-27 gene polymorphism and susceptibility of rheumatoid arthritis in Chinese Han population.
OBJECTIVE To investigate the relationship between IL-27 gene polymorphism and the susceptibility of rheumatoid arthritis (RA) in a Chinese Hans population. METHODS 310 RA patients and 310 healthy controls were examined in this study. Polymerase chain reaction- restriction fragment length polymorphism (PCR-RFLP) technique was used in the detection of the genotype in three loci of IL-27 gene (-...
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ژورنال
عنوان ژورنال: Genetics and Molecular Research
سال: 2018
ISSN: 1676-5680
DOI: 10.4238/gmr16039915